Pal-AHK (Palmitoyl Tripeptide-3) 200mg

Price: $198.00 | Ships Today if Ordered by 12 PM PST.

You’re looking at Pal-AHK, 200mg of pure, research-grade peptide. Think of it as the copper-binding workhorse for cell culture studies. The “Pal” prefix means it’s been lipidated—attached to a palmitoyl fatty acid tail. This isn’t just for show. In experimental models, that modification is believed to enhance lipophilic solubility, potentially allowing for better epidermal penetration and absorption compared to the standard tripeptide. You get the core mechanism with a potential delivery advantage.

Here’s what the published literature points to. In vitro studies on dermal fibroblasts show that the AHK-Cu complex may significantly support cell proliferation and viability. The data is compelling: assays like sulforhodamine B staining and neutral red uptake indicated increased fibroblast growth. More importantly, research reported that collagen type I production in culture media spiked—up to 300% more than control cells. That’s the main structural protein in the extracellular matrix (ECM).

The proposed action is multifunctional. It appears to support the expression of key growth factors within fibroblasts and may activate matrix metalloproteinases (MMPs) for ECM remodeling. There’s also in silico docking data suggesting a potential interaction with VEGFR2, a key receptor in angiogenesis pathways, which could support vascular growth in experimental models.

Furthermore, studies on dermal papilla cells (DPCs) are of particular interest. Research indicates AHK-Cu may stimulate DPC proliferation and hair follicle elongation in vitro. The mechanism appears to involve modulating apoptotic pathways—elevating the Bcl-2 to Bax protein ratio and decreasing markers like cleaved caspase-3. It also may influence growth factor secretion, potentially increasing VEGF while decreasing TGF-β1.

Bottom Line: This is a potent, research-focused tripeptide for controlled in-vitro investigation into ECM synthesis, fibroblast activity, and dermal papilla cell behavior. The data is in the studies. Your research does the talking.

All orders ship same day if placed by 12 PM PST.