N-Acetyl Semax (25mg) – Research Grade

Price: $62.70 | Ships same day if ordered by 12 PM PST.

Here’s the deal on N-Acetyl Semax. Think of it as the upgraded, more resilient version of the classic Semax peptide. The core sequence is the same—that critical Met-Glu-His-Phe fragment—but it’s been modified. The acetylation at the N-terminus and the added Pro-Gly-Pro tail at the C-terminus are the key differences. In simple terms, these changes are believed to do two main things for researchers: significantly boost its stability against breakdown and potentially enhance its ability to cross the blood-brain barrier. That means a longer half-life and potentially more robust activity in relevant experimental models.

We’re talking about a serious research compound. The existing body of work on standard Semax points to significant potential in areas of cognitive function and neuroprotection. Studies suggest it may influence key pathways, notably involving Brain-Derived Neurotrophic Factor (BDNF). In models, Semax has been observed to upregulate BDNF and its receptor, trkB, in hippocampal regions—actions fundamentally linked to neuronal survival, plasticity, and memory processes.

Further research indicates potential interactions with other systems. It may modulate serotonergic activity, as suggested by observed changes in serotonin metabolite levels. It also appears to influence enkephalinase activity, potentially affecting endogenous enkephalin levels. In models of ischemic challenge, Semax has been noted to suppress markers of inflammation and cell death (like JNK and c-Fos) while supporting protective signaling (like CREB activation). Other research points to region-specific effects, such as potential protective actions on gastric mucosa and optic nerve tissue.

The bottom line for your lab: N-Acetyl Semax takes that established research profile and aims to improve its pharmacokinetic properties. The molecular tweaks are designed for better stability and bioavailability. If your work involves studying cognitive function, neuroprotection, neural repair, or related biochemical pathways, this acetylated analog is a precise tool designed for enhanced performance in controlled experimental settings.

Specifications & Details

• Purity: >99% (HPLC verified)
• Molecular Formula: C37H51N9O10S
• Molecular Weight: 858.97 g/mol
• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
• Quantity: 25mg per vial
• Form: Lyophilized (freeze-dried) powder

Important Research Notice

This product is a chemical for research use only. It is NOT intended for human or animal consumption, diagnostic use, or therapeutic application. It is strictly for in-vitro laboratory analysis and experimentation in controlled settings. By purchasing, you confirm you are a qualified researcher or licensed professional operating within a legitimate laboratory environment. You agree to adhere to all applicable laws and regulations regarding the handling and use of research chemicals. All information presented is for educational and scientific discussion purposes.

References: 1. Magrì et al., J Inorg Biochem. 2016. 2. Kaplan et al., Neurosci Res Commun. 1996