Nonapeptide-1 (200mg) | Melanostatine-5 Research Peptide

You’re looking at a precision tool for melanogenesis research. This is Nonapeptide-1, a 9-amino acid sequence (Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val) engineered to be a potent, selective antagonist of the melanocortin-1 receptor (MC1R). In the lab, it’s shown a consistent capacity to disrupt the signaling pathway that upregulates melanin production. Think of it as a high-specificity blocker for studies focused on pigment cell activity.

The data is clear. Research models indicate Nonapeptide-1 operates by competitively binding to the MC1R, inhibiting activation by α-MSH. This action appears to downregulate key components of the melanin synthesis machinery: tyrosinase, TRP-1, TRP-2, and MITF. The result in experimental settings is a measurable reduction in melanin output. Published pilot studies on conditions like melasma have noted a consistent decrease in melanin index scores versus control groups. It’s a straightforward mechanism with a direct observed outcome.

Specifications:

• Purity: >98% (HPLC verified)
• Sequence: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂
• Molecular Formula: C61H87N15O9S
• Molecular Weight: 1206.52 g/mol
• Synonym: Melanostatine-5
• Format: Lyophilized powder in sterile vial

Beyond core pigment research, secondary investigative avenues exist. The role of MC1R in certain cellular proliferation models has prompted inquiry. Studies using similar MC1R antagonists have observed reduced growth rates and morphological heterogeneity in specific tumor cell lines. Furthermore, the presence of MC1R in neural tissues like the periaqueductal gray suggests potential research applications in nociception pathways, though direct data with Nonapeptide-1 is required.

This is for controlled laboratory use by qualified personnel. It is a research chemical. It is not for human or animal consumption, nor is it a cosmetic, diagnostic, or therapeutic agent. You are responsible for understanding and complying with all local, state, and federal regulations regarding the handling and use of this material. By purchasing, you confirm you are a licensed researcher or qualified professional operating in a legitimate laboratory environment.

Ordering Details:

• Price: $240.90
• Quantity: 200mg vial
• Shipping: Orders placed before 12 PM PST ship same day.
• Documentation: Certificate of Analysis provided.

If your work requires a direct, high-potency MC1R antagonist to probe melanocyte function and pigment synthesis pathways, this is your compound. The structure is optimized, the target is clear, and the research history provides a solid foundation for experimental design.